iPET 演講

Post date: 2010/5/14 上午 01:14:00

昨天下午林口長庚邀請 Clifton Shen of Crump Institute 演講 "iPET application",

中午醫技系萬永亮主任，以及核醫科閻紫宸主任特地在雨果餐廳宴請 Clifton Shen ，並討論可能合作議題!

會議開始由魏伯介紹 Crump institute

Selective slides as follow，PDF講義參見附件!

Dr. Shen is the director of Crump Cyclotron Facility and Radiochemistry Technology Center and an Assistant Professor in the Department of Molecular and Medical Pharmacology in David Geffen School of Medicine at UCLA. He has extensive experience across a broad spectrum of scientific disciplines. Primarily, he was trained as a synthetic and physical organic chemist with a particular bent towards synthetic methodology, organometallic and fullerene/polymer chemistry. During his postdoctoral research at Northwestern, he conducted biochemical studies related to nanobiotechnology, including investigations of virus infection and cell adhesion using nanoarrays. In addition, he acquired an extensive knowledge in automated radiochemistry, fabrication of microfluidic devices, and also developed a valveless

injector for a miniature chip-based HPLC system as a senior research scientist at Siemens Biomarker Research Center. During the past years, his lab has developed microwave-assisted radiochemistry and integrated microfluidic devices for radiolabeling biomolecules.

Dr. Shen’s group specializes in radiochemistry and microfluidics and is indeed compose of a highly interdisciplinary team (organic chemists, radiochemists, applied physicists/engineers, and a machinist). In the radiochemistry part, his research focuses mainly on radiofluorination of aromatic compounds and radiolabeling of biomolecules, specifically on developing the ability to perform a variety of chemical/radiochemical reactions and conduct PET probe syntheses using microfluidic platforms, microwave reactors and related hybrid systems. His group collaborates closely with Crump faculty members, UCLA cyclotron facility, materials science groups and other nanotechnology groups and scientific community to develop: (1) reliable and simple solutions to produce 18F-labeled tags for radiolabeling of biomolecules; (2) microwave-assisted radiochemistry; (3) microfluidic-based synthesizers for producing small-molecule-/biomolecule-based PET probes; (4) flexible, module-based platforms capable of adopting different chemical/ radiochemical reaction syntheses; (5) miniaturized purification/QC/QA systems that can be interfaced with robotic radiochemistry modules or microfluidic devices; and (6) novel characterization methods to identify reaction products directly sampled from microfluidic synthesizers, as well as to assay their

compositions and purities.

In the microfluidic part, besides screening optimal condition for radiolabeling of biomolecules or small molecules, his group is also exploring the new applications using the novel microfluidic platforms. For example, microfluidic droplet mixers can be used to produce nanoparticles and hydrogel nanocomposites for in vitro/in vivo gene/protein delivery. The main idea is to enable rapid high-throughput screening of different conditions for producing nanoparticles/nanocomposite with desired properties using microfluidic platforms. The ultimate goal of his research is to establish a easy-to-use yet versatile microfluidic platform enabling researchers to screen many components or conditions quickly for their research projects.